Whooping Cough on the Rise as Experts Push for Next-Generation Vaccines
As pertussis cases surge globally following a lull during the COVID-19 pandemic, the spotlight is turning to advancements in vaccines to combat this highly contagious respiratory disease. Reports indicate that pertussis cases in the European Economic Area in early 2024 outpaced all of 2023, raising alarms about the effectiveness of current vaccination strategies.
A Mother’s Harrowing Experience
Juliet Lautenbach, a civil servant from Canberra, Australia, recounts a grueling encounter with whooping cough that left her and her young daughter struggling to breathe. Despite both being vaccinated, they contracted the illness from a workplace exposure. Lautenbach recalls weeks of relentless coughing and her daughter’s severe symptoms, exacerbated by asthma, which required multiple emergency hospital visits.
“The vaccine may have saved her life, but I later learned that its effectiveness wanes over time,” she said.
Vaccination Efforts and Challenges
Pertussis vaccination, introduced in 1948 as part of the DTP combination vaccine, has drastically reduced fatalities, especially in children. Yet, current vaccines face growing limitations. Acellular vaccines, used in wealthier countries, are safer but less enduring in effectiveness compared to whole-cell vaccines still employed in many lower-income regions.
Dr. Camille Locht, research director at Inserm, notes that immunity from acellular vaccines diminishes faster, with protection dropping from 98% in the first year to as low as 42% after four years among adolescents. “Simply increasing booster shots isn’t a sustainable solution,” Locht warns.
Evolving Bacteria and a Changing Demographic
Strains of Bordetella pertussis are evolving, reducing vaccine effectiveness, while infection demographics shift. Previously seen mostly in unvaccinated infants, pertussis now disproportionately affects adolescents aged 10 to 19, whose immunity from childhood vaccines has waned.
Experts like Daniela Hozbor from Argentina’s La Plata National University emphasize the urgency of new solutions. “Preventing pertussis through vaccination is crucial,” she says, noting its rapid spread—up to 90% of susceptible individuals can contract it within an hour of exposure.
A Nasal Vaccine on the Horizon
Locht and his team are developing a third-generation vaccine, BPZE1, which uses live but weakened bacteria. Early trials show promise, with immunity lasting longer than current options and stimulating protection in the nasal mucosa, where the infection begins.
Kingston Mills, an immunology professor at Trinity College Dublin, underscores the potential of nasal vaccines. “They generate strong immune responses in the nasal cavity and lungs, where the infection occurs,” he says.
BPZE1 is slated for phase 3 clinical trials in 2025, with distribution potentially starting by 2027. Meanwhile, public health experts continue to stress the importance of booster shots and maternal vaccination to protect the most vulnerable.
As pertussis resurges, the race to deploy innovative vaccines offers hope for curbing the disease’s impact worldwide.
Technology
Chinese Memes Take Over American Social Media Amid Rising Tech Tensions
Despite growing tensions between the United States and China over national security and trade, Chinese internet culture is experiencing an unexpected surge in popularity among American social media users. From viral memes about industrial chemicals to an influx of U.S. users on Chinese platforms, the digital space has become an unlikely bridge between the two nations.
One of the most surprising trends of 2024 was the rise of Donghua Jinlong, a Hebei-based manufacturer of industrial glycine, an amino acid used in food production. Though an obscure company, its advertisements on TikTok unexpectedly went viral, transforming the brand into an internet sensation. American users, dubbing themselves “glycine girlies,” embraced the meme, creating influencer-style content about a product they had no actual use for.
Diana R., the creator behind the popular meme account CitiesbyDiana, explained the phenomenon. “We spent an entire month pretending we were buying industrial chemicals from China and making videos as if it were a luxury brand,” she said. The meme became so widespread that it was covered by major publications, including The Washington Post and The New Yorker. Donghua Jinlong even played along, sending merchandise to online creators.
TikTok Ban Sparks Migration to RedNote
The viral fascination with Chinese memes coincides with a new wave of American users flocking to RedNote (Xiaohongshu), China’s version of Instagram. This sudden migration was triggered by the brief implementation of a TikTok ban over national security concerns, before President Donald Trump granted the platform a 75-day reprieve.
In just a few days, around three million Americans joined RedNote, integrating into a platform with 300 million predominantly Chinese users. The result was an unexpected cultural exchange, as users swapped jokes, shared memes, and even helped each other with homework.
American internet users have long speculated about what lies beyond China’s “Great Firewall”, which restricts access to many Western social media platforms. But RedNote has emerged as one of the few Chinese apps accessible overseas, allowing U.S. users to engage with Chinese netizens in a way that was previously rare.
A Cultural Exchange Beyond Politics
Even as U.S. leaders push for restrictions on Chinese tech companies, internet culture appears to be bridging the geopolitical divide. One of the most popular viral phrases to emerge from RedNote is “you swan, he frog,” a Chinese idiom originally used to describe relationships with mismatched expectations. After being posted by an American influencer, it quickly spread across English-speaking social media, applied to everything from celebrities to politicians.
The rise of Chinese memes in the U.S. reflects a growing curiosity about Chinese internet culture, despite political narratives urging division. Jianqing Chen, an East Asian languages and cultures researcher at Washington University in St. Louis, believes social media plays a crucial role in fostering connections between everyday citizens. “Grand political narratives lose their power at the level of everyday interaction,” he said. “Personal engagement online allows people to see beyond tensions and recognize shared human experiences.”
Even amid discussions of trade wars and national security threats, social media continues to show that humor—and memes—transcend borders.
Technology
DeepSeek’s Rise Shakes AI Industry, Sends Shockwaves Through US Tech Sector
A new AI app from China, DeepSeek, has sent shockwaves through the tech industry, markets, and the prevailing belief in American dominance in artificial intelligence (AI). The app’s meteoric rise has raised questions about the future of the AI sector, as well as the cost-effectiveness of AI development.
Venture capitalist Marc Andreessen referred to the launch of DeepSeek as AI’s “Sputnik moment,” drawing comparisons to the Soviet Union’s launch of the Sputnik satellite, which triggered the space race. Over the weekend, DeepSeek became the most downloaded free app on Apple’s US App Store, and by Monday, it was already having a profound effect on the markets. The app’s launch sparked a massive sell-off of major tech stocks, including a 17% plunge in the share price of AI chipmaker Nvidia, which lost nearly $600 billion in market value — the largest drop in US stock market history, according to Bloomberg.
What has stunned Silicon Valley is the claim by DeepSeek’s developers that the app was built for just $5.6 million — a fraction of the billions spent by AI giants like OpenAI, Google, and Anthropic. While OpenAI spent $5 billion in 2023 alone, DeepSeek’s developers suggest that this low cost could signal a breakthrough in AI development, potentially disrupting the established industry.
In a growing sense of disbelief, many in the tech world have been left questioning DeepSeek’s viability and the accuracy of its financial claims. Some analysts have speculated that the app’s success could indicate a shift in how AI is developed and delivered, with lower costs and fewer resources than previously thought necessary. DeepSeek’s models reportedly use open-source software and existing technology, which has led some to speculate that its use of Nvidia’s H800 chips may have been facilitated by stockpiling during the past years.
The development has also spurred concerns about US dominance in the sector, as the country has long assumed its control over high-end chips and data centers gave it an advantage in the AI race. However, China’s sudden emergence as a serious player with DeepSeek has led many to reconsider the global balance of power in AI.
Billionaire Sam Altman of OpenAI, who has largely stayed quiet on the matter, did comment late on Monday, acknowledging DeepSeek’s “impressive” performance. While Altman reaffirmed OpenAI’s position as a leader in AI, he welcomed the competition, calling it invigorating.
DeepSeek’s arrival has left many observers unsure of what the future holds for US semiconductor giants and raised broader questions about the long-term implications of AI development. With this new development, China has flexed its muscles in the AI sector, making clear that the race for dominance is far from over, and the US may no longer have a clear upper hand.
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