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A landmark study has revealed that more than 39 million people worldwide could die from antibiotic-resistant infections over the next 25 years, with an additional 130 million potentially succumbing to related causes. The study, published in The Lancet, highlights the escalating threat of antimicrobial resistance (AMR) as global leaders prepare to address the issue at a high-level meeting in New York.

AMR occurs when bacteria and other pathogens evolve to resist antibiotics, often due to overuse in medicine, agriculture, and animal farming. This resistance has led to a significant increase in the difficulty of treating infections. Since 1990, AMR-related infections have killed approximately one million people annually, according to the study conducted by the Global Research on Antimicrobial Resistance (GRAM) Project.

The study, which analyzed 520 million records across 204 countries, projects that by 2050, AMR could directly cause 1.91 million deaths and contribute to 6.31 million deaths from related causes. “This is really a very silent pandemic, and it’s growing,” warned Ahmed Ogwell, vice president of global health strategy at the UN Foundation. “Our attention needs to be there now.”

From 1990 to 2021, the study found a 60 percent reduction in AMR-related deaths among children under five, thanks to improved vaccination programs and infection control. However, deaths among adults aged 70 and older surged by more than 80 percent during the same period, highlighting the growing vulnerability of aging populations.

The study also noted that regions such as South Asia, sub-Saharan Africa, and parts of Latin America and the Caribbean are expected to face significant impacts due to AMR. Lower- and middle-income countries are particularly challenged, as many lack access to antibiotics, compounding the issue.

In high-income countries, annual AMR-attributable deaths are anticipated to increase from 125,000 to 192,000 between 2021 and 2050. This underscores the need for urgent action across all regions, regardless of economic status.

Next week, the United Nations General Assembly will hold its second high-level meeting on AMR since 2016. Global leaders are expected to endorse a political commitment to combat AMR, although recent negotiations have diluted some targets. For example, a goal to reduce antimicrobials in animal farming by at least 30 percent was replaced with a less specific promise to “strive meaningfully” to reduce usage.

Dr. Sally Davies, the UK’s special envoy on AMR, has called for stronger governance, improved data collection, and incentives for pharmaceutical companies to develop new antibiotics. She also advocates for an independent scientific panel on AMR and greater focus on the risks to food systems and the environment.

The Lancet study suggests that significant reductions in AMR deaths could be achieved with improved infection control, broader vaccinations, and better antibiotic stewardship. For instance, better access to antibiotics and enhanced infection care could prevent 92 million deaths between 2025 and 2050.

As global leaders prepare to tackle this growing crisis, the study highlights the need for a coordinated response and individual actions, such as proper hand hygiene and responsible antibiotic use.

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Engine Fire on Cathay Pacific Airbus A350 Linked to Fuel Leak, Investigators Reveal

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An engine fire aboard a Cathay Pacific Airbus A350 earlier this month was caused by a fuel leak, according to an investigation by Hong Kong’s Air Accident Investigation Authority (AAIA). The incident, which occurred in early September, prompted the airline to ground its A350 fleet following a turn-around flight due to an “engine component failure.”

The engine involved, a Rolls-Royce Trent XWB-97, suffered a malfunction shortly after departing from Hong Kong en route to Zurich. Pilots received a cockpit fire warning, shut down the affected engine, and deployed fire extinguishers. The aircraft, carrying 348 passengers and crew, made a safe emergency landing back in Hong Kong.

A preliminary report from the AAIA indicates that a broken fuel hose—among several damaged hoses—caused the fire. The protective cover of the fuel hose had ruptured, creating a “discernible hole” and leaving signs of soot and burn marks. The report highlights that other defective fuel hoses in the same engine could have led to a more severe fire if not promptly addressed.

The AAIA has recommended that the European Union Aviation Safety Agency (EASA) mandate new inspection protocols for the Trent XWB engines. In response, EASA has introduced inspections of fuel pipes and the removal of potentially compromised hoses. The agency also broadened its inspection requirements to include multiple variants of the Trent XWB engine after discovering that a specific cleaning process during engine refurbishment could degrade the fuel hoses.

Cathay Pacific has stated that it conducted a comprehensive fleet-wide inspection of its A350 aircraft and is fully compliant with EASA’s directives. The airline assured that it continues to collaborate closely with airframe and engine manufacturers as well as regulators to ensure safety.

The Airbus A350, which first entered service in 2016, is favored for its efficiency and low operating costs. The Trent XWB engine, developed by Rolls-Royce specifically for the A350, is central to the aircraft’s performance. Although the fire raised concerns about potential widespread issues affecting the global A350 fleet, it was soon determined that the problem was limited to the external fuel lines, not the engine’s internal components.

Rolls-Royce has committed to supporting the ongoing investigation and emphasized that the engine and aircraft systems effectively managed the incident. The company is also investing in improvements to its engine range, including the Trent XWB-97, in response to industry feedback.

The incident underscores the importance of rigorous safety inspections and timely responses to potential aviation hazards, ensuring continued confidence in the Airbus A350 and its Trent XWB engines.

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Samsung Electronics Faces Major Disruption in India Amid Prolonged Worker Strike

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For the past 11 days, around 1,500 workers at Samsung Electronics’ Chennai plant in Tamil Nadu have been on strike, causing significant disruptions to production. The Chennai facility, one of Samsung’s two factories in India, employs nearly 2,000 workers and is crucial to the company’s revenue, contributing about a third of its annual $12 billion (£9 billion) earnings from India.

The striking workers are demanding recognition of their newly-formed union, the Samsung India Labour Welfare Union (SILWU). They argue that only a union can effectively negotiate better wages and working conditions. The protest, one of Samsung’s largest in recent years, comes amid Prime Minister Narendra Modi’s efforts to attract foreign investment by positioning India as an alternative to China for manufacturing.

Samsung India has stated that worker welfare is a priority and that discussions are ongoing to resolve the issues. “We have initiated discussions with our workers at the Chennai plant to resolve all issues at the earliest,” the company said.

Earlier in the day, police detained around 104 workers for participating in an unauthorized protest march but released them later. The workers have vowed to continue their strike indefinitely until their demands are met. According to A Soundararajan from the Centre of Indian Trade Unions (CITU), which supports the new union, the workers are asking for union recognition, collective bargaining rights, and the exclusion of competing unions. About 90% of the workforce is reportedly aligned with SILWU.

The striking workers, who earn an average monthly salary of 25,000 rupees ($298; £226), are seeking a 50% raise over the next three years. They also allege unsafe working conditions, including excessive pressure to meet production targets and prolonged work hours without adequate breaks. Samsung India has denied these allegations, asserting that all workers receive suitable breaks and work in compliance with labor laws.

Tamil Nadu’s Labour Welfare Minister CV Ganesan has assured union officials that talks are underway to address their concerns. “We will fulfill the demands of the workers,” he said.

The protest highlights ongoing issues in India’s labor market, where multinational corporations often face criticism for inadequate labor practices. Labor economist Shyam Sundar notes that firms frequently use strategies to prevent unionization, such as promoting internal, company-controlled unions over external ones. He also points to the rise of contractual labor, which can be used to maintain a more compliant workforce.

As global companies, including Apple and Amazon, establish operations in India, labor rights activists argue that many underpay and overwork employees while resisting compliance with local labor laws. The situation at Samsung’s Chennai plant reflects broader challenges facing workers in India’s rapidly evolving industrial sector.

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Bank of England Holds Interest Rates at 5%, Signals Gradual Rate Cuts Ahead

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The Bank of England has maintained its base interest rate at 5%, with Governor Andrew Bailey indicating a gradual reduction in borrowing costs may be on the horizon. Bailey noted that while inflation has decreased significantly, the Bank will require more evidence of sustained low inflation before implementing further rate cuts.

Inflation remained at 2.2% last month, slightly above the Bank’s target. The decision to hold rates was widely anticipated, following a reduction from 5.25% in August—the first cut since the pandemic began in 2020. Bailey expressed optimism about future rate decreases but stressed the importance of caution to avoid cutting rates too quickly or excessively.

“The decision to keep rates steady was guided by the need to address persistent inflationary pressures,” Bailey said. He added that inflation must remain low to justify any further reductions. The base interest rate influences borrowing costs, affecting mortgages, credit cards, and savings returns. While higher rates have led to increased borrowing costs, they have also benefited savers.

The elevated rates have impacted many households, including James and Sofia, who recently moved to a smaller home due to rising rent. Their rent had increased by £100 a month to £1,650, prompting their move to a £1,400 rental property. Sofia, who had to return to work early from maternity leave due to financial strain, reported challenges such as relying on food banks and struggling with fuel costs.

Despite these issues, the Bank of England’s latest assessment suggests some positive economic developments. Mortgage approvals have risen to their highest level since September 2022, and there are reports of improving real incomes. However, the Bank anticipates inflation will climb to around 2.5% towards the end of the year, with the UK economy showing signs of gradual improvement.

Bailey noted that the economic impact of major global events, including the Covid-19 pandemic and the Ukraine war, has lessened. “We’ve managed to navigate past the severe effects of these global shocks,” he said, though he acknowledged that economic recovery has been slow. The Bank expects economic growth between July and September to be 0.3%, down from the 0.4% expansion previously anticipated.

The UK economy has experienced sluggish growth in recent years, prompting the new Labour government to pledge reforms aimed at revitalizing economic performance. The Bank of England’s cautious approach reflects ongoing concerns about inflation and economic stability as it looks to balance rate adjustments with broader economic conditions.

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