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A large new study has found that women with a history of endometriosis or uterine fibroids may face an increased long-term risk of dying before the age of 70, particularly from gynaecological cancers. The study, published in the British Medical Journal, examined over 110,000 women aged 25 to 42 who participated in the Nurses’ Health Study II, a decades-long investigation into chronic disease risk factors among women.

Endometriosis, which affects about 10 percent of women of reproductive age, is a condition where tissue similar to the lining of the uterus grows outside of it. Fibroids, non-cancerous growths in or around the uterus, affect an estimated two-thirds of women during their lifetime, according to the UK National Health Service (NHS). Both conditions have been linked to various health problems, but this new study highlights their potential connection to early mortality.

The researchers found that women with endometriosis had a 31 percent higher risk of premature death compared to those without the condition. The study revealed that women with endometriosis experienced an all-cause death rate of 2 per 1,000 person-years, compared to 1.4 per 1,000 among women without the condition. This increased risk was mainly driven by deaths from gynaecological cancers.

While fibroids were not associated with an overall increase in early death, the study did find that women with fibroids had a higher risk of dying from gynaecological cancers. The authors of the study suggested that women with a history of endometriosis or fibroids might face a heightened long-term risk of early death, extending beyond their reproductive years.

The study, which spanned from 1989 to 2019, was observational in nature, meaning it identified associations but could not establish direct causality. However, the researchers pointed out that both endometriosis and fibroids have been previously linked to chronic diseases such as hypertension, heart disease, and certain cancers, though their impact on premature mortality had been unclear until now.

Gynaecologist Francisco Carmona praised the study’s methodology, calling it “robust and well-founded.” He emphasized the importance of considering gynaecological diseases in the broader context of women’s health, noting that the study reinforces the need for early and personalized management. Carmona also pointed out that further research should address the impact of evolving diagnoses and treatments, such as ovary removal surgery, on long-term health outcomes.

The study’s findings underline the importance of early diagnosis and treatment for women suffering from these conditions, with potential implications for both clinical practice and health policy.

Health

Tackling Burnout in Remote Work: Strategies for Sustaining Mental Well-being

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Tackling Burnout in Remote Work

Remote work has become a transformative force in professional life, offering unparalleled flexibility and removing the need for daily commutes. However, it also introduces unique challenges that can exacerbate occupational burnout. Research from the International Labour Organization (ILO) indicates that remote workers are more prone to mental health issues than their in-office counterparts. This article explores evidence-based strategies to effectively combat burnout in the remote work environment.

1. Establish Clear Work-Life Boundaries

One of the most pressing challenges of remote work is maintaining a clear separation between professional duties and personal life. Without boundaries, the risk of burnout increases. To address this:

  • Set specific working hours and adhere to them rigorously.
  • Create a dedicated workspace to mentally separate work from leisure.
  • Turn off work-related notifications outside of work hours to allow complete detachment.

2. Integrate Regular Breaks into Your Routine

Traditional office environments naturally include breaks, but these often vanish in remote settings. To replicate their benefits:

  • Take short breaks every 60-90 minutes to recharge both mentally and physically.
  • Use these pauses for movement, such as walking or stretching, to counteract sedentary habits.
  • Avoid electronic devices during breaks to facilitate mental relaxation.

3. Develop a Consistent Daily Routine

Establishing a structured schedule enhances productivity and reduces stress. Begin each day by prioritizing tasks and adhering to a realistic plan. A well-organized framework supports efficiency while minimizing the risk of feeling overwhelmed.

4. Prioritize Physical and Mental Health

Physical health underpins psychological resilience. Adopt habits that enhance both:

  • Engage in at least 30 minutes of physical activity daily, whether aerobic exercise, yoga, or resistance training.
  • Maintain a balanced diet and avoid eating at your desk to encourage mindful eating.
  • Develop a relaxing pre-sleep routine to ensure restorative rest, which is essential for combating fatigue.

5. Seek Emotional Support When Needed

Acknowledging emotional distress and seeking assistance are vital steps toward recovery. Platforms such as LiveThera provide access to licensed therapists who can offer personalized guidance to manage stress and emotional challenges effectively.

6. Recognize Early Warning Signs of Burnout

Identifying the initial indicators of burnout is crucial for timely intervention. Common symptoms include:

  • Persistent exhaustion that doesn’t improve with rest.
  • Reduced motivation and lower productivity levels.
  • Heightened irritability or a tendency to withdraw from social interactions.

If these symptoms arise, consider consulting a mental health professional for targeted strategies to mitigate burnout.

7. Utilize Employer-Sponsored Mental Health Programs

Many organizations now provide mental health support tailored to remote work challenges. LiveThera collaborates with companies to deliver workshops and individualized sessions, fostering employees’ psychological resilience and preempting burnout.

Conclusion

Remote work offers significant advantages but requires intentional effort to manage its inherent challenges. By implementing these strategies, individuals can maintain their mental well-being while maximizing the benefits of remote work. Additionally, professional support from services like LiveThera ensures that help is available when needed. This holistic approach is essential for creating sustainable remote work practices that promote long-term mental health.

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Global Pandemic Treaty Faces Stalemate as Negotiations Stall Ahead of 2025 Deadline

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Efforts to finalize a global pandemic treaty to prevent another COVID-19-style crisis have hit a deadlock, leaving little hope that the agreement will be completed by the May 2025 deadline.

After three years of discussions, countries involved in the negotiations have made limited progress. The most recent round of talks, which concluded this month, revealed ongoing disagreements on key aspects of the treaty. These include pandemic prevention measures and the creation of a system for sharing pathogen information and ensuring equitable access to vaccines and medicines.

The treaty, first proposed in 2020 by European leaders, was designed to address gaps exposed during the COVID-19 pandemic, particularly around global cooperation and equitable access to healthcare resources. One of its main goals was to reduce inequalities between wealthier nations and developing countries by ensuring that vaccines and treatments would be available to all, regardless of income.

“A pandemic knows no borders, so international collaboration is a must,” said Jaume Vidal, senior policy advisor at Health Action International. However, the treaty’s negotiations have been hindered by diverging priorities. Developed countries push for stronger disease surveillance and preparedness in the global south, while developing nations are concerned about the financial burden and demand greater access to the benefits of shared information.

More than 190 countries are involved in the talks, which are facilitated by the World Health Organization (WHO). The treaty was originally scheduled for completion by May 2024, but this was postponed to May 2025 due to the lack of agreement on critical issues.

Europe has advocated for stronger prevention measures, requiring developing nations to enhance their health systems. However, many African countries have expressed concerns about the costs of implementing such measures, fearing they could place additional burdens on already strained resources. Additionally, these countries seek priority access to vaccines and treatments developed from the pathogen data they provide, a point that has sparked tension with wealthier nations with large pharmaceutical industries.

Civil society groups have criticized the process, with some warning that lower-income countries are being pressured into accepting watered-down provisions. “Developing countries are hesitant because they lack the resources to meet prevention obligations,” said Piotr Kolczynski, Oxfam International’s health policy advisor. “They’re also frustrated by the lack of flexibility from rich countries on other matters.”

With the deadline fast approaching, informal talks are expected in early 2025, but negotiators caution that the formal discussions scheduled for later that year may not be enough to resolve the deadlock.

The uncertainty is further compounded by political factors, including the possibility of a return to power by former U.S. President Donald Trump, whose administration was critical of the WHO. His reelection could stall the process or push for further dilution of the treaty’s provisions.

As the political momentum for the treaty fades, some experts worry that the longer negotiations drag on, the less likely it will be that a strong, effective treaty will emerge.

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New HIV Injection Shows Promise, But Access Remains a Challenge

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A new twice-yearly injection has shown unprecedented effectiveness in preventing HIV infections, with a 96% success rate in men, but experts warn that the key challenge now is ensuring access to those who need it most.

The injection, called lenacapavir, has been hailed as one of the closest advancements the world has seen to an HIV vaccine. It was found to be significantly more effective than the daily oral pill PrEP (pre-exposure prophylaxis), which has long been a primary HIV prevention method. Lenacapavir is already approved in several countries, including the US, Canada, and Europe, under the brand name Sunlenca for the treatment of existing HIV infections. It was previously shown to be 100% effective in preventing HIV in a study involving women.

“This is so far superior to any other prevention method we have, that it’s unprecedented,” said Winnie Byanyima, executive director of UNAIDS, praising drugmaker Gilead for developing the medication. However, she emphasized that the fight to end AIDS hinges on how the drug is distributed, particularly in at-risk countries.

Gilead has agreed to allow generic versions of the drug to be sold in 120 poor countries with high HIV rates, primarily in Africa, Southeast Asia, and the Caribbean. However, Latin America, where HIV rates are lower but rising, has been excluded from this deal. This has raised concerns among health experts and activists that the region may be missing a crucial opportunity to curb the spread of HIV.

In a report issued for World AIDS Day on Sunday, UNAIDS noted that the number of AIDS-related deaths dropped to an estimated 630,000 last year, the lowest since the peak in 2004. The report suggested that the world is at a “historic crossroads” in the battle against the epidemic, with a real chance to end it.

Lenacapavir’s potential benefits are particularly significant for marginalized groups, such as gay men, sex workers, and young women, who often face stigma or fear seeking regular HIV prevention care. UNAIDS’ Byanyima called the drug a “miracle” for these groups, as it only requires a visit to a clinic twice a year for protection.

Luis Ruvalcaba, a 32-year-old man from Guadalajara, Mexico, who participated in the recent study, explained that he had avoided requesting daily pills due to fears of discrimination. Now, as a study participant, he will continue receiving the injection for at least another year.

Despite these advancements, access to lenacapavir in countries like Mexico remains uncertain. Health officials in Mexico have not commented on whether the drug will be available through the public health system, although daily HIV prevention pills were made available for free in 2021.

In response to growing concerns, advocacy groups in Latin America, including countries like Peru, Argentina, and Chile, have written to Gilead requesting access to generic versions of Sunlenca. They argue that as infection rates rise, the need for new, more effective HIV prevention tools is critical.

AIDS expert Dr. Salim Abdool Karim from South Africa’s University of KwaZulu-Natal stressed that while lenacapavir is one of the most effective prevention tools ever seen, the real challenge now lies in ensuring it reaches everyone who needs it.

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